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Author

Zhiyuan Chen

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Open access Sep 2026

Hierarchical chromatin polyvalency governs robust gene regulation and organogenesis

Ch chromatin polyvalency model is established as a multi-layered, hierarchical repression mechanism that governs temporal control of gene expression during embryogenesis and disrupts temporal control of polyvalent gene activation.

Cheng-Jie Zhou, Meng Wang, Zhi-Yuan Chen et al. · 0 citations
Open access Aug 2026

YAP Promotes Microtubule Growth to Facilitate Sarcomere Disassembly in Adult Cardiomyocytes

It is shown that microtubule expression and network density decline with cardiac maturation, which identifies microtubule networks as an essential regulator modulating CM dedifferentiation and sarcomere reorganization, which is critical for CM cytokinesis and cardiac regenerative repair.

Feng Zhang, Jenna Cusick, Jie Liang et al. · 1 citation

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