Author

Zhi-Yuan Chen

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Open access Sep 2026

Intratumoral microbiota-host gene associations characterize stage-associated microecological patterns in colorectal cancer

Intratumoral microbiota are emerging as important ecological components of the colorectal cancer (CRC) microenvironment. However, their stage–associated patterns and coordination with host gene expression remain poorly understood. This study aimed to characterize stage–associated associations between intratumoral m...

Zhi-Yuan Chen, Wen-Xuan Gan, Fang Cao et al. · Frontiers in Microbiology · 0 citations

Review Open access Sep 2026

Interleukin-11 Signaling in Liver Disease: Mechanisms, Cellular Crosstalk, and Therapeutic Potential

The liver has a remarkable regenerative capacity, but persistent injury caused by drugs, metabolic dysfunction, alcohol, and chronic inflammation can overwhelm this process and promote fibrosis and hepatocellular carcinoma. Interleukin-11 (IL-11), a cytokine that signals through glycoprotein 130 (gp130), was historical...

Zhi-Yuan Chen, Fan Yu, Yan-Hua Qiu et al. · Biomolecules · 0 citations