Author

Zhifeng Gu

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Aug 2026

JOSD2 attenuates the aggressive behavior of fibroblast-like synoviocytes in rheumatoid arthritis by deubiquitinating and stabilizing ZNF148.

Increased JOSD2 attenuates the aggressive behaviors of RA-FLS and alleviates synovial inflammation, and the JOSD2-ZNF148 axis may represent a potential therapeutic strategy for RA.

Teng Wu, Qingshui Wen, Yu-Nan Wang et al. · International Immunopharmaco... · 0 citations

Jul 2026

Calycosin triggers ferroptosis through modulation of the OTUD6B/GPX4 axis to suppress triple-negative breast cancer.

This is the first study to demonstrate that Cal exerts anti-TNBC activity through a novel OTUD6B/GPX4-dependent ferroptosis regulatory axis and highlights that Cal warrants further investigation as a potential candidate, and the OTUD6B/GPX4 signaling pathway may represent a significant target for TNBC treatment.

Xue Mao, Yin Lin, Zhifeng Gu et al. · Biochemical and Biophysical... · 0 citations