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Author

Zhigang Ju

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Review Jul 2026

Pharmacological targeting of the extracellular cGAMP-ENPP1 axis in cancer immunotherapy: mechanisms, biomarkers, and translational strategies.

The mechanistic basis, pharmacological rationale, and translational challenges of targeting the extracellular cGAMP-ENPP1 axis in cancer are summarized and a biomarker-guided framework incorporating cGAMP-generating capacity, ENPP1 expression and enzymatic activity, STING-response competence, and on-treatment pharmacodynamic conversion is proposed.

Kailang Mu, Rui-qi Liao, Jun Xie et al. · 0 citations