Open access
Jul 2026
A biocatalytic platform for the stereoselective synthesis of diverse atropisomeric compounds using engineered metalloenzymes
Atropisomeric compounds are widely distributed in natural products and pharmaceuticals and serve as key scaffolds in asymmetric catalysis. Despite their remarkable structural diversity, current synthetic efforts have primarily focused on C–C biaryl atropisomers, while the synthesis of other classes of atropisomeric com...
Xiaochen Cai, Dong Cui, Yuchen Chu et al.
· Science Advances · 0 citations