Author

Zhiheng Xu

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Review Open access Oct 2026

Gut microbiota-driven imbalance of the gut-brain-immune homeostatic network in constipation: Pathogenic mechanisms and evolving therapeutic prospects

Summary Chronic constipation (CC) is increasingly recognized as a systems-level disorder that cannot be explained by impaired intestinal motility alone. Here, we integrate evidence from clinical cohorts, animal models, and mechanistic studies to examine how gut microbial dysbiosis and altered microbial metabolites pert...

Jia-Ning Zhu, Bin-Bin Zeng, Wen-Xu Zhu et al. · iScience · 0 citations

Review Open access Aug 2026

Multi-omics landscapes across the gastritis-to-carcinoma sequence: Stage-specific molecular evolution and microenvironmental remodeling

Studies investigating the gastritis-to-carcinoma sequence using genomics, epigenomics, transcriptomics, proteomics, metabolomics, and microbiome analyses provide valuable insights into gastric carcinogenesis while highlighting the need for cautious interpretation and translational validation.

Jiayin Ou, Jia-Xing Lin, Yuyang Cao et al. · iScience · 0 citations