Follicle-stimulating hormone promotes energy metabolism in bovine granulosa cells through the FOXO1-ISG15 pathway to maintain the development of multiple follicles
A mammalian model of multi-follicular development using pFSH and integrated single-cell transcriptomics with functional analyses uncovered a regulatory axis governing the metabolism and proliferation of granulosa cells (GCs), revealing the pivotal role of the pFSH–FOXO1–ISG15 regulatory axis in orchestrating GC metabol...