Review
Open access
Jul 2026
Targeting the unfolded protein response in cancer: mechanisms, small-molecule inhibitors, and translational challenges
This review integrates recent mechanistic insights into UPR-driven tumor progression, including pathway crosstalk, immune regulation, and immunotherapy resistance, with advances in small-molecule inhibitors, while critically evaluating their therapeutic potential and translational challenges in cancer treatment.
Meizhen Lin, Zhijie Li
· Frontiers in Immunology · 0 citations