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Zhilong Zhang

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2025

Rationalized All-Atom Protein Design with Unified Multi-Modal Bayesian Flow

This work proposes the first Bayesian flow formulation for protein backbone orientations by recasting orientation modeling as an equivalent hyperspherical generation problem with antipodal symmetry and delivers consistently exceptional performance in both peptide and antibody design tasks.

Hanlin Wu, Yuxuan Song, Zhe Zhang et al. · 0 citations
Preprint Jul 2026

Spectral Rewiring for Exploration, Purification, and Model Merging

Subspace-Aligned Rewiring (SAR) shows that extracting reasoning-effective updates from parameter geometry can serve as a training-free mechanism to improve reasoning and multi-domain performance.

Zhilong Zhang, Hongli Yu, Huan Gao et al. · 0 citations