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Author

Zhimin Hu

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Open access Aug 2026

Emerging roles of ATR beyond DNA damage repair: orchestrating transcriptional reprogramming during epithelial-to-mesenchymal transition

Two pivotal studies published in this issue of JCI provide key insights into how ATR intersects with EMT transcriptional reprogramming and uncovered a role for ATR in ECM stiffness–induced EMT, which was associated with an immunosuppressive tumor microenvironment.

Aida Mestre-Farrera, Zhimin Hu, Jing Yang · 0 citations
Open access Jul 2026

A three-gene signature correlated with MAPK/ERK activation characterizes acquired resistance to EGFR-tyrosine kinase inhibitors in non-small cell lung cancer

It is suggested that MAPK/ERK signaling contributes to the transition from adaptive tolerance to stable resistance to afatinib and highlight a tractable therapeutic vulnerability for overcoming resistance to tyrosine kinase inhibitors in NSCLC.

Chang-Tai Qin, Wei Zhang, Dongfang Tang et al. · 0 citations

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