Author

Zhipeng Zhu

2 papers indexed here

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Oct 2026

CEBPB integrates OSM signaling and eIF4G2-mediated alternative translation to configure enhancer landscape and sustain oncogenic CHI3L1 in glioblastoma.

BACKGROUND CEBPB is a critical driver of mesenchymal transformation and aggressiveness in glioblastoma (GBM). However, fundamental questions remain regarding its dynamic regulation within the GBM microenvironment and its precise mechanistic role in orchestrating the epigenetic and transcriptional reprogramming. METHO...

Ji-Yang Liu, Ying Zhang, Xiao-Ping Yi et al. · Neuro-Oncology · 0 citations

Open access Aug 2026

Targeted degradation of P-TEFb via MDM2 substrate substitution collapses oncogenic transcriptional programs in MDM2-amplified cancers

MDM2 is an oncogenic E3 ubiquitin ligase best known for targeting the tumor suppressor p53 and is frequently amplified in human cancers, including dedifferentiated liposarcoma (DDLPS). We show that supraphysiological MDM2 expression can be exploited to reprogram its ligase activity toward selective degradation of o...

Ye Chen, Long Xie, Xian Guan et al. · Cell Death & Disease · 1 citation