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Author

Zhiwei Chen

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Sep 2026

Twenty-year persistence of SARS-CoV-1 immune imprinting shapes antibody responses to SARS-CoV-2 infection.

Study of individuals sequentially infected with SARS-CoV-1 and SARS-CoV-2 over two decades and found durable imprinting of antibody responses following SARS-2 BF.7 breakthrough infection defines the remarkable longevity and molecular basis of antibody imprinting and provides insights for pan-sarbecovirus vaccine design...

Qi Zhang, Peng Chen, Feng-Lin Guo et al. · 0 citations
Open access Jul 2026

SARS-CoV-2-induced IL-6 paralyzes DC function through maturation impairment and immunosuppressive DC3 expansion 2256903

A novel immune-evasion pathway wherein SARS-CoV-2-induced IL-6 expands immunosuppressive DC3s via C/EBPβ is unveiled, highlighting IL-6 and C/EBPβ as promising therapeutic targets for ameliorating DC dysfunction in severe COVID-19 and related hyperinflammatory disorders.

Run-Hong Zhou, Zhiwei Chen, Na Liu · 0 citations
Jul 2026

MOT-SR: Multi-Objective Tool-Augmented Scientific Equation Discovery with Large Language Models

Multi-Objective Tool-augmented Symbolic Regression (MOT-SR), a unified framework that integrates external analytical tools to extract structural priors and guide equation generation, while jointly optimizing for accuracy, complexity, and generalization via a multi-objective evaluation module that maintains a dynamic Pa...

Boxiao Wang, Runxian Wang, Kai Li et al. · 0 citations

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