Author

Zhiwei Chen

3 papers indexed here

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Oct 2026

Targeting the HIF-1α-BSG metabolic circuit reverses enzalutamide resistance in prostate cancer.

BACKGROUND Enzalutamide resistance limits durable control of castration-resistant prostate cancer (CRPC), but the mechanisms coordinating metabolic adaptation, cellular plasticity, and residual androgen receptor (AR) signaling remain incompletely understood. We investigated whether BSG, encoding basigin/CD147, contribu...

Xiu-Chen Guo, Jia-Cheng Huang, Zhi-Wei Chen et al. · Cellular Signalling · 0 citations

Open access Sep 2026

TMEM59L promotes neuroendocrine differentiation and enzalutamide resistance in prostate cancer by regulating MUC1/β‐catenin/MYC axis

Abstract Background Enzalutamide resistance in advanced prostate cancer often leads to treatment‐induced neuroendocrine prostate cancer (t‐NEPC), characterized by aggressive lineage plasticity. The molecular regulators governing neuroendocrine differentiation and phenotypic transition are not well understood. Here, we...

Xiu-Chen Guo, Yi-Fan Liu, Jia-Cheng Huang et al. · Clinical and Translational M... · 0 citations

Open access Jul 2026

MANF safeguards mitochondria-associated endoplasmic reticulum membrane integrity in nucleus pulposus-derived mesenchymal stem cells to maintain homeostasis of the intervertebral disc.

BACKGROUND Intervertebral disc (IVD) degeneration (IDD) is a leading cause of low back pain, with limited treatment options. The degenerative disc's harsh microenvironment promotes nucleus pulposus-derived mesenchymal stem cells (NP-MSCs) death and hinders self repair. Mesencephalic astrocyte-derived neurotrophic facto...

Chen-Hao Zhao, Liang Kang, Jiaqi Wang et al. · Cell Biology and Toxicology · 0 citations