Author

Zhong Li

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Open access Aug 2026

Discovery and Characterization of Inhibitors of Ubiquitin Like Modifier Activating Enzyme 5 (UBA5): Targeting the UFMylation Pathway in Cancer and Neurodegenerative Disease

A robust high-throughput screening assay based on AMP-Glo™ and a library of blood–brain barrier–permeable compounds are developed, identifying five inhibitors spanning three distinct scaffolds with low micromolar potency that establish UBA5 as a tractable enzymatic target and provide first-in-class chemical tools to pr...

Vigyasa Singh, Yuansong Wan, Zhisong Gao et al. · ACS Chemical Biology · 0 citations

Review Open access Aug 2026

Target-Based Antiviral Drug Development Against Human Respiratory Viruses

This review examines the principles and applications of target-based antiviral drug development against human respiratory viruses, emphasizing the identification and exploitation of conserved viral and host targets.

S. K. Samrat, Gaurie Srivastava, Ran Zhang et al. · Pathogens · 0 citations

Jul 2026

Biochemical characterization and assay development for adenylosuccinate synthetase Rv0357c from Mycobacterium tuberculosis.

The expression, purification, and enzymatic characterization of recombinant Mtb ADSS are reported, providing the first comprehensive biochemical framework for studying Mtb ADSS and establishing a foundation for structure-guided inhibitor discovery targeting purine biosynthesis as a novel antitubercular strategy.

Vigyasa Singh, Ran Zhang, Ke Chen et al. · Biochimica et Biophysica Act... · 0 citations