Author

Zhouchun Chen

2 papers indexed here

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Open access Sep 2026

Functional-genomic prioritization identifies MED12 as a candidate RNAi vulnerability in acute myeloid leukemia: evaluation of a T22 peptide-functionalized LNP-siRNA formulation

Background Acute myeloid leukemia (AML) depends in part on transcriptional and epigenetic programs that can be difficult to target with conventional small molecules. RNA interference provides a potential approach to perturb such vulnerabilities, but target selection and intracellular siRNA delivery remain major challen...

Zhou-Chun Chen, Tian-Ran Chai, Mei-Chen Liu et al. · Frontiers in Pharmacology · 0 citations

Review Open access Sep 2026

Brain-Targeting siRNA Delivery to Tackle Alzheimer's Disease.

Both the therapeutic promise and the realistic limitations of siRNA-based approaches for AD are discussed, priorities for future development are outlined, and key gaps that must be addressed are identified to enable meaningful clinical implementation.

Qingshan Yang, Zhou-Chun Chen, Jian-Chao Zhu et al. · Wiley Interdisciplinary Revi... · 0 citations