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Zhu-Jun Mao

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Sep 2026

HUWE1-mediated ubiquitination and degradation of TTC4 aggravates allergic rhinitis via inhibiting PINK1/parkin-dependent mitophagy and promoting FKBP5/NF-κB-induced Treg/Th17 imbalance: HUWE1-mediated TTC4 ubiquitination and degradation aggravates AR.

BACKGROUND Previously, we proved that tetratricopeptide repeat domain 4 (TTC4) protected against inflammatory injury in allergic rhinitis (AR). This study further explored whether HECT, UBA, and WWE domain containing protein 1 (HUWE1) functions as an E3 ubiquitin ligase targeting TTC4 to participate in AR pathogenesis....

Yu-Ting Huo, Zhi-Hui Liu, Zhu-Jun Mao et al. · 0 citations

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