BACKGROUND
We previously developed a tier-based germline classification using the National Comprehensive Cancer Network (NCCN)-recommended DNA damage repair (DDR) genes and KLK3 I179T to predict prostate cancer (PCa)-specific mortality (PCSM). To provide an easier-to-use single inherited risk score while preserving gen...
Jun Wei, Zhu-Qing Shi, Lucy Lu et al.· The Prostate· 0 citations
IMPORTANCE
Patients diagnosed with breast cancer (BCa) are at increased risk of multiple common diseases; however, the spectrum of these diseases and the contribution of inherited genetic susceptibility remain incompletely characterized.
METHODS
We evaluated 15 common diseases and tested their associations with BCa e...
Annabelle Ashworth, Zhu-Qing Shi, Huy Tran et al.· JNCI Cancer Spectrum· 0 citations
Suggestive evidence supporting associations between rare germline variants in eight hereditary cancer genes and lung cancer were obtained from two large independent datasets.
Sierra R. Broad, Jun Wei, Keri L. Denson et al.· Annals of Thoracic Surgery· 0 citations
An integrated continuum genetic risk model, GenProb-PCa, improves PCa risk stratification beyond binary approaches by capturing heterogeneity in inherited risk and may enable more precise risk-based screening strategies.
Zhu-Qing Shi, A. Mulford, Jun Wei et al.· Journal of Medical Genetics· 0 citations
Germline PVs in NCCN-recommended DDR genes and the KLK3 I179T variant identify a subset of men at elevated risk of PCSM, including those with apparently localized disease.
Lucy Lu, Julian Xu, Zhu-Qing Shi et al.· Prostate Cancer and Prostati...· 1 citation
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