PURPOSE
To examine the association between MetS, its five components (central obesity, hypertension, hyperglycemia, dyslipidemia, and hypertriglyceridemia) and RAO, and to assess whether genetic susceptibility to key components of the MetS (hypertension, hyperglycemia) interacts with these associations.
METHODS
Based...
Chun-Ran Lai, Zicheng Wang, Jia-Hui Cao et al.· Retina· 0 citations
The retina, as an extension of the central nervous system, shares a common embryological origin with the brain. In Alzheimer's disease (AD), studies of human tissue and animal models have revealed that hallmark AD pathologies, including amyloid-β (Aβ) deposits and pathological tau protein tangles, also appear in the re...
Xia-Yin Zhang, Dongli Zhuang, Chun-Ran Lai et al.· Progress in retinal and eye...· 0 citations
It is revealed that spatially defined immunometabolic remodeling—in which Trem2 + microglia are central—converges on sphingolipid metabolism as a druggable regulatory axis, with the TREM2‐SPTLC2 interface thus emerging as a new therapeutic opportunity for retinal neurodegenerative diseases.
Yun-Hong Shi, Jinpei Lin, Yi Wu et al.· iMeta· 0 citations
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