Aerobic Exercise Ameliorates Osteoarthritic Chondrocyte Degradation in Osteoarthritis via Regulating E2F8/NLRP14 Signaling Pathway.
Although physical activity is known to mitigate disease risks, its protective molecular mechanisms remain poorly understood. E2F8, a regulator of cell cycle and metabolism, showed significant differential expression between osteoarthritis (OA) and exercise models, suggesting it may link mechanical activity to OA allevi...