Open access
Sep 2026
ISGylation promotes ALDOA stability and PKM2-dependent activation to fuel colorectal cancer metabolism
ISG15 overexpression in cancers has emerged as a diagnostic marker and therapeutic target. This study identifies ISGylation, a post-translational modification mediated by ISG15, as a critical driver of CRC progression through metabolic reprogramming and oncogenic signaling. Clinical and multi-omics analyses reveal el...
Ye Wang, Peng Yang, Chi Jin et al.
· Cell Death & Disease · 0 citations