Zi-Gan Sha

Mimotope-Guided Molecular Dynamics Enables Precise Functional Epitope Mapping.

Mimotopes selected by phage display have been used for antibody epitope mapping for nearly four decades, but residue-level recovery of functional epitopes has remained unreliable. This is not a problem of algorithms but of assumptions: mimotopes recapitulate native epitope recognition through compensatory interaction n...