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Author

Zi Guo

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Sep 2026

Unraveling the regulatory nexus of aggrephagy in ALS: identification of novel candidate biomarkers and molecular triggers

Through S100a6 overexpression and knockdown experiments in an NSC34 motor neuron-like ALS model, it is found that S100a6 impaired autophagy and promoted SOD1 aggregation, further validate its potential as a biomarker and provide new insights into the pathogenesis of ALS.

Ying-Zhen Zhang, Ken-Hui Wei, Han-Xiao Lin et al. · 0 citations
Aug 2026

Correlation analysis between complement proteins and Alzheimer's disease

These findings suggest that microglia may contribute to complement-mediated pathological processes associated with AD, and alterations in their levels may reflect early pathological changes in AD and warrant further investigation.

Ying-Tong Lu, Zi Guo, Meng-Yuan Liu et al. · 0 citations

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