Sep 2026
NNV mediates the activation of the NLRP3 inflammasome through mtDNA release and oxidative DNA damage.
The NLRP3 inflammasome is a cytoplasmic multiprotein complex that is activated under stress or infection conditions. It promotes the maturation of IL-1β by cleaving pro-Caspase-1, thereby playing a critical role in host innate immune responses. Various viruses can differentially activate NLRP3 through distinct mechanis...
Li-Fang Cao, Runbin Huang, Lu Yang et al.
· Fish and Shellfish Immunolog... · 0 citations