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Zi-Han Xiong

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Open access Oct 2026

Somatic-to-germline concordance rates in clinically actionable cancer predisposition genes.

540 Background: Somatic tumor testing increasingly identifies pathogenic variants (PVs) that inform cancer treatment decisions. Per 2019 ESMO guidelines, many somatic PVs in cancer susceptibility genes warrant confirmatory germline genetic testing (gGT). Approximately 4-40% of patients have somatic PVs meeting...

Abigail Macher, Zi-Han Xiong, Vicky Ro et al. · 0 citations

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