Open access
Sep 2026
2′-deoxyinosine ameliorates multiple sclerosis through modulating Th1/Th2 and Th17/Treg cell balance with potential involvement of AMPK phosphorylation
Background Multiple sclerosis (MS) is an autoimmune and neurodegenerative disease characterized by T lymphocyte infiltration and demyelination that can lead to severe disability without treatment. However, effective treatment for MS remains an unmet need. 2′-deoxyinosine (2′-DI), an endogenous nucleoside, has been impl...
Da-Qing Wang, Jia-Xuan Zhu, Zhuo Wang et al.
· Frontiers in Pharmacology · 0 citations