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Zi-Jing Zhu

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Sep 2026

SDHB deficiency promotes renal fibrosis by triggering mtRNA leakage and activating the RIG-I-MAVS pathway.

It is demonstrated that SDHB is down-regulated in fibrotic kidneys, and mechanistic insights into how TCA cycle disruptions and mtRNA leakage interactions drive renal inflammation are provided, suggesting SDHB as a potential therapeutic target for renal fibrosis.

Zi-Jing Zhu, Ping Chen, Hong-Xin Shu et al. · 0 citations

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