Zi-Xin Chen

B-194 Bile Acid Metabolomics Reveals Distinct Immunometabolic Niches and Enables Accurate Diagnosis of AQP4-IgG–Seronegative NMOSD

Distinguishing neuromyelitis optica spectrum disorder (NMOSD) from multiple sclerosis (MS) remains clinically consequential, particularly in patients seronegative for anti–aquaporin-4 IgG (AQP4-IgG), for whom objective biomarkers are limited. Because bile acids (BAs) mediate gut microbiota–host signaling and immu...