Nickel-Catalyzed cis-Arylation of Unactivated gem-Difluoroalkenes: A Pathway for the Construction of a Fluorinated Amino Acid Molecular Library.
Because of their intrinsic inertness, the selective functionalization of unactivated gem-difluoroalkenes represents a formidable challenge in organofluorine chemistry. Herein, we report a picolinamide-directed, nickel-catalyzed strategy that enables the stereoselective arylation of unactivated gem-difluoroalkenes incor...