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Open access Sep 2026

Ginsenoside Rg5 mitigates adenine-induced renal fibrosis by regulating the SIRT7/NETs/NLRP3 pyroptosis axis.

This study examined the protective effects of Rg5 against renal fibrosis and elucidated its underlying immunomodulatory mechanisms. A mouse model of renal fibrosis was generated through adenine administration, and Rg5 was administered orally to assess its preventative effects. Renal tubular epithelial cells (RTECs, HK-...

Jiang-Tao Zhong, Zi-Yi Xu, Ze-Long Wang et al. · 0 citations
Sep 2026

Dietary Supplementation of Auraptene, a Major Component in Citrus reticulata Blanco, Prevents Acute Liver Injury Associated with Apoptosis and Inflammation

Auraptene (AP), a coumarin derivative abundant in citrus peels, exhibits diverse bioactivities; however, its role in acute liver injury and the underlying mechanisms remain elusive. This study investigates the hepatoprotective effects of AP against carbon tetrachloride (CCl4)-induced acute liver injury in mice and ex...

Tao Guo, Zi-Yi Xu, Xin-Ting Li et al. · 0 citations

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