The biological rationale for ferroptosis-targeted cancer therapy is summarized, major translational barriers are analyzed, and nanomedicine strategies that may move ferroptosis induction from experimental proof of concept toward clinically interpretable intervention are synthesized.
Yan-Pin Ma, Zi-Yi Xu, Huda Akram et al.· Frontiers in Molecular Biosc...· 0 citations
This review systematically elucidates the multidimensional regulatory mechanisms of m6A on ferroptosis regulatory factors, covering post-transcriptional modifications of the System Xc−/GSH/GPX4 antioxidant axis, iron metabolism-related proteins, and key enzymes of lipid peroxidation.
Yu-Shuo Duan, Zi-Yi Xu, Jia-Hao Liang et al.· Frontiers in Cell and Develo...· 0 citations
This review systematically summarizes the molecular mechanisms and common pathways through which PTMs contribute to therapeutic resistance in liver cancer, explores PTM-mediated mechanism underlying tumor persistence and distant recurrence, andamines how PTM-targeted strategies may reverse resistance.
Si-Min Feng, Jie Hu, Xiao-Xi Guo et al.· Frontiers in Immunology· 0 citations
ABSTRACT Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths, its progression and treatment heterogeneity are mainly influenced by driver gene and tumor micro-environment (TME) interactions. Nevertheless, the mechanisms of this process at the single-cell level remain unclear. This study integrate...
MP-GCZ represents a promising comprehensive approach to overcoming TME-mediated resistance and may offer a valuable solution to enhance the clinical efficacy of cancer immunotherapy.
Xin-yu Gu, Sheng-Wei Shen, Yu-Ting He et al.· Materials Today Bio· 0 citations
This review critically synthesizes the multifaceted roles of RNA modifications to bridge the gap between descriptive epitranscriptomic mapping and functional tumor biology, and aims to facilitate the translation of epitranscriptomic findings into clinical applications.
