Author

Zi-Yi Zhou

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Sep 2026

Scutellaria barbata D.Don suppresses SPP1+ polarization in tumor-associated macrophages via the HIF-1α/STAT3 signaling to attenuate hepatocellular carcinoma progression.

ETHNOPHARMACOLOGICAL RELEVANCE Scutellaria barbata D.Don (SBD) is used for the treatment of hepatocellular carcinoma (HCC) as an alternative therapy in East Asia. Previous studies have shown that SBD can suppress the progression of HCC. However, the precise mechanism of SBD, particularly within the tumor immune microen...

Jia-Cheng Lin, Li-Ping You, Wen-Li Yuan et al. · Journal of Ethnopharmacology · 0 citations

Sep 2026

Matrine induces ferroptosis and suppresses colorectal cancer through targeting the STAT3/SLC7A11 pathway.

Matrine, a natural alkaloid with recognized anti-cancer potential, has been reported to induce cancer cell death. However, the mechanism remains incompletely defined. In this study, we investigated the pharmacological effect of matrine on colorectal cancer (CRC) using both in vivo tumor‑bearing mouse models and in vitr...

Hong-Jie Yu, Yu-Li Wang, Yuan Fang et al. · Biochemical Pharmacology · 0 citations