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Open access Sep 2026

Stratifying Alzheimer’s disease by patient-specific genetic signatures reveals cognition-linked and cross-disease heterogeneity

Alzheimer’s disease (AD) presents profound clinical and genetic heterogeneity that obscures its biological underpinnings and impedes therapeutic development. While genome-wide studies have identified population-level risk loci, the architecture of patient-specific genetic variation and its link to clinical outcomes rem...

Jia-Hui Zhang, Zi-Yu Yu, Xing-Cai Zhang et al. · 0 citations

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