Author

Zi-Zhen Zhang

2 papers indexed here

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Oct 2026

SPP1+ TAMs drive colorectal tumorigenesis through an ARG2-orchestrated metabolic-immune crosstalk.

Rising incidence of colorectal cancer (CRC) and limited therapeutic options highlight the urgent need to define the drivers of its progression. The SPP1+ tumor-associated macrophage (TAM) subset identified by single-cell transcriptomics is a functionally dominant population that extends beyond the classical M1/M2 parad...

Lin-Hong Song, T. Yan, Shi-Yuan Lu et al. · Cancer Letters · 0 citations

Open access Sep 2026

Extracellular vesicle proteins monitor and interfere with CLDN18.2-targeted CAR-T cell and antibody therapies against gastrointestinal cancers

Claudin 18.2 (CLDN18.2)-targeted CAR-T cell and antibody therapies show promise against gastrointestinal cancers, but biomarkers predictive of long-term benefit and therapeutic sensitization strategies are needed. Here we show that proteins carried by circulating extracellular vesicles (EVs) can reflect and influence t...

Chang-Song Qi, Ming-Yang Ma, Kai-Jie Liang et al. · Nature Communications · 0 citations