Zihan Li

PHGDH: metabolic enzyme or signaling hub? From broad-spectrum inhibition toward context-adapted therapeutic targeting.

Phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the de novo serine synthesis pathway (SSP), has emerged as a context-dependent metabolic hub that integrates glycolysis, one-carbon metabolism, redox homeostasis, and epigenetic regulation. It is regulated by a multi-layered network encompassing transc...