Author

Zikun Ma

2 papers indexed here

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Oct 2026

MDK+ cancer-associated fibroblasts promote immunotherapy resistance through mitochondrial reprogramming in breast cancer.

Immunotherapy has improved outcomes for patients with breast cancer, yet therapeutic resistance remains a major clinical challenge. Therefore, we integrated single-cell and spatial transcriptomic data from breast cancer cohorts treated with immune checkpoint inhibitors to identify resistance-associated cellular populat...

Wei Deng, Yi-Dan Fan, Han-Qi Zhang et al. · Cancer Letters · 0 citations

Aug 2026

Tumor cells recruit macrophage bodyguards to outlast chemotherapy.

In Cell Press Blue, Carvalho et al. identify spatially organized tumor-macrophage niches, EMT-like CD44high cancer cells paired with SPP1/PARP14high macrophages, that drive chemoresistance in bladder cancer. PARP14 inhibition can flip this protective niche into an inflammatory, cisplatin-sensitizing state.

Yuzhao Wang, Zibin Chen, Zhuo-Wei Liu et al. · Cancer Cell · 0 citations