Zingales

Mechanistic insights into deoxynivalenol-induced cytotoxicity in an SH-SY5Y 3D spheroid model.

Investigating the cytotoxic effects of DON and its underlying mechanisms using a 3D spheroid model derived from the human neuroblastoma cell line SH-SY5Y demonstrates that DON induces cytotoxic effects in SH-SY5Y spheroids, accompanied by mitochondrial alterations, increased mitochondrial superoxide production, and apoptotic cell death.