ONC201 enhances the radiosensitivity of small-cell lung cancer via inhibition of the FAK signaling pathway
Summary Small-cell lung cancer (SCLC) is a highly aggressive neuroendocrine malignancy with a poor prognosis. Radiotherapy is an essential treatment strategy for SCLC but is constrained by rapid relapse and therapeutic resistance. ONC201, an orally bioavailable imipridone compound, has demonstrated clinical efficacy ag...