Protein language models are trained primarily with masked language modeling (MLM), which predicts masked amino-acid identities, but joint-embedding predictive architectures (JEPA) instead predict latent representations, but have not been applied to proteins.
Neural networks, particularly message-passing neural networks (MPNNs), are increasingly used as heuristics for hard combinatorial optimization problems. Yet many learning-based methods rely on supervision, reinforcement learning, or gradient estimators, causing high computational cost, unstable training, or limited gua...
Chendi Qian, Christopher Morris, Stefanie Jegelka et al.· 0 citations
We introduce a new multivariate statistical problem that we refer to as the Ensemble-conditioned Inverse Problem (EIP). The aim of EIP is to invert for an ensemble that is distributed according to the pushforward of a prior under a forward process. In high energy physics (HEP), this is related to a widely known problem...
Zheng-Yan Huan, C. Pazos, Martin Klassen et al.· 0 citations
Diffusion models are state-of-the-art tools for various generative tasks. Yet training these models involves estimating high-dimensional score functions, a task that in principle suffers from the curse of dimensionality. It is therefore important to understand how low-dimensional structure in the target distribution ca...
Georg A. Gottwald, Shuigen Liu, Youssef Marzouk et al.· 0 citations
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This work introduces a class of random polytopes which simultaneously generalizes several known constructions and indicates how these properties can be exploited for classification and clustering tasks in data analysis.
This work establishes and discusses local geometric mixing bounds through Dobrushin contraction, and applies this approach to Diffusion Path Monte Carlo, a recently proposed Markov chain Monte Carlo method aimed at leveraging advances in score-based modeling.
LLM leaderboard gains can reflect selection among privately evaluated model variants, yet neither the number of variants nor their dependence is public. We ask how many hidden variants a published margin can support while retaining statistical evidence of a provider's advantage over a fixed comparator. For a fixed cand...
This work introduces Neural Process Boosting (NPBoost), which decomposes structured response variability into tree-boosted fixed effects shared across tasks and NP random effects that capture stochastic task-to-task variation.
Andrea Nava, Ken Rölli, Armin Begić et al.· 0 citations
Data assimilation estimates a dynamical state from partial and noisy observations. Classical ensemble filters are efficient but restrict analysis updates through finite sample covariance and affine Gaussian distribution. We introduce the Flow Ensemble Filter (FlowEF), which uses conditional flow matching to transport t...
JTS-SCB forms a bounded sensitivity envelope over candidate tilts, but its calibration-only construction does not inherit the exact finite-sample weighted-conformal guarantee, so experiments show that strong plug-in predictive sampling can match the oracle when the shift is well identified, while sensitivity analysis i...
We propose a Bayesian nonparametric mixture of regression trees with a Dirichlet process prior over tree-parameter pairs, enabling data-driven selection of ensemble size and unifying CART, BART, random forests, and boosting. A novel splitting rule driven by the posterior predictive of a Gaussian process within each ter...
A normal--inverse-gamma (NIG) latent hierarchy has four parameters, but its induced latent law does not identify all four. For $\sigma^2\sim\mathrm{InvGamma}(\alpha,\beta)$, $\mu\mid\sigma^2\sim\mathcal{N}(\gamma,\sigma^2/\nu)$, and $z\mid\mu,\sigma^2\sim\mathcal{N}(\mu,\sigma^2)$, the marginal law of $z$ depends on $(...
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Is your company’s AI sovereign? A practical guide for CIOs on AI vendor lock-in, EU Data Act switching, cloud sovereignty, and testing your exit plan before you need it. The post Sovereignty Is the Option to Leave appeared first on GPT-Lab.
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