Writing involves diverse cognitive activities, from ideation to revision, and writers' needs vary across individuals and moments. Proactive AI promises to provide the right support at the right time, yet existing proactive tools largely focus on generic textual assistance, such as autocomplete. This paper studies the design space of proactive thought partners: AI agents that proactively offer customizable, higher-level cognitive support during writing. We instantiated this concept in a technology probe and deployed it with 16 participants for one week. The probe allows users to create partners by configuring their roles and proactivity. As users write, relevant partners take the initiative at appropriate moments to offer suggestions. Our findings show that participants configured proactive support through prospective planning, used suggestions for both idea generation and self-monitoring, and valued lightweight visual representations alongside non-directive rhetorical framing for non-intrusive interventions. We derive implications for designing proactive writing assistants around customization, timing, engagement, and representation.
Chao Zhang, Abe Davis, Chih-Wei Chen et al.· 0 citations
Medical image segmentation remains difficult to scale because high-performing methods typically rely on dense expert annotations and task-specific training. We introduce GazeRefine, a training-free framework that uses gaze as an inference-time prompt for zero-shot medical image segmentation. Sparse, duration-weighted fixations are converted into foreground and background priors that initialize semantic prototypes in frozen DINOv3 feature space. These prototypes are iteratively refined through foreground-background discrimination, feature-space affinity propagation, and anchoring to the initial gaze guidance, allowing segmentation to extend beyond directly fixated regions while limiting semantic drift. GazeRefine requires no segmentation masks, fine-tuning, adapters, prompt encoders, or gradient updates. We evaluate the method on gaze-annotated polyp segmentation and prostate MRI segmentation. The results show strong performance on colonoscopy images and competitive performance on prostate MRI, supporting gaze-guided prototype refinement as a promising approach for segmentation-label-efficient, human-in-the-loop medical image segmentation. Our tools and code can be found in the following repository: https://github.com/MohammedOussamaBEN/GazeRefine.git
Mohammed Oussama Benyahia, Marouane Tliba, Mohamed Amine Kerkouri et al.· 0 citations
Using a large language model to play the user is now standard in scalable evaluation. It has a repeatedly diagnosed failure: the simulated user is excessively cooperative, so a system under test can score by the sheer number of questions it asks rather than by making the user willing to speak. We answer with a disclosure gate conditioning information release on the companion agent's behaviour: its state is a ladder of five ordered gates, merged onto three observable depth layers. We specify, ablate, and audit it, and train a user simulator against that specification. Gating behaviour is learned from the training corpus's synthetic branch, while the real branch supplies how people speak and react; after training, the simulator need not be told at runtime which gate each item sits behind. The gate is a load-bearing component of the environment: on the English corpus of a published companion-agent benchmark (CompanionBench), once training no longer states per example which gate each item sits behind, the largest rank displacement across 12 systems under test exceeds the noise band set by re-running that environment under a new seed, while per-system scores show no detectable change. We state two acceptance criteria: a ranking must be order-preserving, and absolute scores must be scale-stable. Of the candidates we examine, only one passes both -- the simulator we release -- and its leaderboard correlates at 0.993 with the benchmark's original simulator. By contrast, prompting a frontier model as the simulator barely moves the ranking while shifting every score upward -- a shift invisible to anyone checking the ranking alone. The environment we specify is the one that benchmark already used. That publication describes the mechanism in about four hundred words, and we supply what it lacked: specification, ablations, human studies, negative controls, and downstream sensitivity analysis.
As far-right actors increasingly exploit online platforms to disseminate ideology and mobilize supporters, civil society organizations (CSOs) play a vital yet underrecognized role in monitoring antidemocratic dynamics online. Unlike fact-checkers or content moderators, CSOs engage in long-term, contextualized analysis, often in resource-constrained settings and under precarious conditions. Despite their critical societal role, CSOs face significant barriers to adopting or co-developing technical solutions, including legal uncertainty, limited platform access, and chronic underfunding. Existing research and tool development efforts have largely overlooked these actors in favor of more institutionally embedded stakeholders. This paper addresses this gap through a qualitative study with 15 practitioners from 12 Germany-based CSOs engaged in online monitoring, positioning them as key yet overlooked stakeholders in the governance of digital spaces. We explore their current practices, challenges, and expectations regarding technological support. Our findings show that monitoring remains largely manual due to the lack of tailored tools, with enhanced search capabilities emerging as the most pressing technical need. While participants express openness to AI-supported features such as media processing and content discovery, many remain skeptical of automated classification, citing concerns around trust, legal usability, and professional credibility. Grounded in these findings, we introduce a conceptual monitoring workflow and describe its implementation in an open-source Telegram monitoring prototype designed to flexibly support diverse monitoring goals. We outline concrete design, policy, and research recommendatios, and introduce the manual labor trap as an empirically grounded concept that explains why monitoring CSOs tend to remain locked into labor-intensive, low-capacity arrangements.
Elisabeth Steffen, Helena Mihaljevic· 0 citations
Reach audiences
Advertise in front of researchers, engineers, and readers.
Computer-use agents are emerging as a paradigm for agentic human-AI interaction, combining language reasoning with multi-modal interface grounding to operate GUIs. Yet their effectiveness for blind screen-reader users in real-world desktop workflows remains unclear. We present a three-week diary study with 8 blind users using OLLA, a screen-reader-accessible CUA prototype, collecting 1,258 commands across 12 applications with screenshots, UI trees, model responses, and action traces. We evaluate GPT-5 during deployment and re-execute the same commands with four additional models. GPT-5 achieved the highest success rate at 52.5%. Trace analysis reveals grounding, planning, constraint-tracking, and termination failures, while interviews reveal beyond-automation needs.
Satwik Ram Kodandaram, Monalika Padma Reddy, Xiaojun Bi et al.· 0 citations
Large language models are powerful, but their interfaces often devolve into a type $\rightarrow$ read $\rightarrow$ retype loop, creating conversational AI fatigue, cognitive load, and eventual task abandonment. To mitigate this, we present RecalibrateGPT, a system introducing five cross-turn operators (Anchor, Replay, Delta, Scope, and Steer) that each target a distinct fatigue type, recalibrating LLM responses through a structured panel by acting on the full conversation history with a single click. Users invoke these operators through the AssistiveButton in one of three operator palette layouts: Vertical, Arc, or Tablet. We conducted two pilot studies with the same 12 advanced LLM users. An initial formative qualitative study identifies a taxonomy of four fatigue types (retyping, scanning, decision paralysis, and context drift) and derives two design objectives for RecalibrateGPT. A follow-up quantitative evaluation finds it reduces perceived cognitive workload by half (NASA-TLX = 2.7) at high perceived usability (SUS = 86.5), suggesting AI fatigue is not just a model-quality issue but an interaction-flow cost that interfaces can remove.
Can an artificial intelligence (AI) generate a scientific hypothesis outside a human collaborator's active hypothesis space (AHS), and can human-AI research be organized to make such breakthroughs more likely? We document such a case while proving a theorem that connects two basic organizing mechanisms of statistical physics: collective behavior arising in zero field from competing interactions and that induced or controlled by an external field. A zero-field $O(n)$-vector open chain with arbitrary inhomogeneous nearest- and next-nearest-neighbor interaction functions $U_i(S_i\cdot{S}_{i+1})$ and $V_i(S_i\cdot{S}_{i+2})$ is microscopically, via a temperature-independent mapping at the Hamiltonian level, equivalent to a simpler $O(n)$ open chain with nearest-neighbor interaction $V_i( \sigma_i\cdot \sigma_{i+1})$ and axial single-spin potential $U_i(\sigma_i^z)$ for every integer $n\ge1$ and every system size $L\ge1$. The homogeneous linear specialization maps the foundational frustrated $J_1$-$J_2$ model onto the canonical $J$-$h$ field model---with $n=1,2,3$ being the Ising, XY, and Heisenberg classical spin models, respectively. An analogous theorem holds when the continuous $O(n)$ spins are replaced by the $q$-state Potts spins with the standard Potts interaction, implying a closed-form exact solution of the $J_1$-$J_2$ Potts open chain for every $q\ge2$ and every $L\ge1$. The emergence of the theorems from sustained human-AI collaboration suggests that involving AI throughout a systematic research program may incubate autonomous scientific breakthroughs.
Does unrestricted AI access bypass the cognitive effort required for learning, or does it streamline knowledge acquisition? This paper reports on a study where we compare three designs for user-AI interaction in a learning context: (1) an unrestricted conversational bot like ChatGPT, (2) a pedagogically constrained bot that guides through hints without giving final answers, which we refer to as the Socratic mode; and (3) a non-conversational adaptive tutoring system that adjusts difficulty in real-time based on the user's cognitive engagement derived from the brain signals. Fifty study participants were tasked with learning about nuclear safety protocols, a domain chosen for its zero-prior knowledge baseline. The participants progressed through an instructional video, a pre-test, an AI-driven assessment phase, which varied in the three conditions, and an immediate post-test. The nature of the questions centered primarily on factual knowledge acquisition, but it still required participants to have a global understanding of the concepts in order to answer the questions correctly. A Muse headband was used to derive the cognitive engagement of all users in all conditions. The unrestricted chatbot produced higher learning gains (delta) than both constrained modes (p < .03, d > 0.80), while the adaptive condition generated significantly higher EEG engagement (p = .018). The cluster analysis of chatbot usage and discussion patterns by users showed that most participants in the unrestricted-mode adopted a direct answer-retrieval strategy, while participants in the Socratic-mode initially attempted to reason through the hints before progressively disengaging. Consequently, this also suggests that the success of the unrestricted AI is not an evidence of deeper learning, but rather a result of the immediate post-test evaluation after the training phase.
Clinical artificial intelligence is increasingly embedded in real-world care, yet existing safety mechanisms are poorly suited to reconstructing and learning from individual AI-related errors and near-misses. Aggregate model monitoring can identify performance changes, and traditional patient safety reporting can capture adverse events, but neither is designed to explain how risk emerges across the interaction among AI systems, clinicians, workflows, and institutional controls. We propose AI Morbidity and Mortality (AI M&M), a structured, blameless framework for case-based review of clinical AI failures. The framework combines standardized case intake, evidence preservation and investigator-level reconstruction, tool-in-loop attribution, and corrective-action tracking. Each event is classified across four linked dimensions: Trigger - Mechanism - Clinical Pathway - Corrective Action, separating the condition that exposed a vulnerability from the process that produced risk, its consequence for care, and the remediation assigned. We demonstrate the framework using five illustrative outpatient medication and clinical decision-support cases; two clinician reviewers independently applied all four classification axes and reached agreement across all 20 axis-level classifications. AI M&M is intended to complement, rather than replace, model monitoring, patient safety reporting, and regulatory oversight by converting individual AI-in-workflow failures into actionable institutional learning. Prospective evaluation across institutions, AI systems, and clinical settings is needed.
Paulius Mui, Dean F. Sittig, Steve Labkoff et al.· 0 citations
AI agents pose significant risks as they are granted increasing autonomy. A commonly proposed solution is human oversight and keeping a''human in the loop'', but this is not a simple solution: Not only do current approaches to AI agent design impede effective human oversight, but the cognitive capacities required for it are also themselves degraded by extended use of AI systems. This position paper argues that current approaches to the development and deployment of AI agent systems do not support effective human oversight -- they contribute to its degradation. To address this, a top priority in the advancement of AI agents should be supporting the situated goals and cognitive requirements of effective human oversight, treating the human needs of overseers at the same level of importance as AI agent capability. To put this idea into practice, we connect work on automation and human-computer interaction to AI agent processes, outlining design-level affordances and organizational protocols that (1) support overseers in exercising critical judgement and (2) counteract the skill atrophy that arises from extended use of automation. We urge developers and deployers to adopt these or similar approaches. Without explicit support for the cognitive demands of effective human-agent interaction, AI agent systems will continue to passively incentivize the degradation of the very human skills they rely on.
Margaret Mitchell, Avijit Ghosh, Samir Passi· 0 citations
Atomic charge is crucial in drug design for analyzing reactive sites and interactions between ligands and targets. While quantum mechanical methods offer high accuracy, they are generally computationally costly. Conversely, empirical approaches, while computationally efficient, frequently suffer from lack of precision and generalizability. Recent a number of machine learning-based models have been developed for atomic charge predictions, but they struggle with accurately representing molecular structures and capturing the chemical environments affecting atomic charges, thus limiting their generalization and accuracy. To overcome these limitations, we propose LumiCharge, a novel atomic charge prediction framework that incorporates high-order spherical harmonics convolutions and explicitly models multibody interactions. In constructing this model, we employ a strategy that integrates both high- and low-order information, enhancing its geometric spatial perception capability, which is currently underexplored in the field. Benchmark evaluations demonstrate that LumiCharge outperforms state-of-the-art (SOTA) models by 30%-60% across diverse data sets. Additionally, in cross-scale experiments, LumiCharge demonstrates exceptional extrapolation capability and robustness across molecules of varying sizes, effectively overcoming the limitations imposed by molecular sizes. On an external halogen-containing test set, LumiCharge achieves an RMSE of 0.055e, meeting practical application requirements. Finally, a case study of virtual screening for the androgen receptor (AR) target further validates its outstanding accuracy compared to the OPLS3e force field and other deep learning (DL)-based baseline models, highlighting its exceptional generalization capacity and practical utility in real-world scenarios.
Qun Su, Hui Zhang, Qiaolin Gou et al.· Journal of Physical Chemistr...· 2 citations
Accurate prediction of the peptide-protein interaction (PepPI) is crucial for developing peptide-based therapeutics and vaccines. However, this computational task has traditionally faced significant challenges, such as the scarcity of structure data along with the corresponding label of the binding affinity for bound complexes. To address these challenges, we introduce PepBAN, a deep learning framework for modeling PepPI predictions. PepBAN incorporates two technical advancements: (1) adopting the protein language model ESM-2 to characterize proteins and ESM-2 or a graph-based foundation model for peptides without structure data and (2) leveraging the conditional domain adversarial learning to enhance generalization across a broad range of protein targets, especially when there are limited binding data. At the core of PepBAN is a bilinear attention network (BAN) that effectively learns the pattern of pairwise local interactions, enables the identification of key residues participating in the peptide-protein interactions, and offers an intuitive approach to interpret the underlying mechanisms of PepPIs via analyzing attention weights. Our numerical experiments demonstrated that PepBAN outperformed the previous state-of-the-art models across several well-established benchmark studies. Furthermore, we evaluated PepBAN's applicability in predicting cyclic peptide-protein interactions, a task that poses significant challenges due to the presence of noncanonical amino acids. These nonstandard residues require specialized handling, which most existing sequence-based PepPI prediction models did not adequately address, and we adopt an atom-resolved molecular graph approach to process cyclic peptides. Despite this complexity, PepBAN demonstrated a clear advantage by achieving a superior prediction performance and offering a distinct edge in tackling the emerging chemical space of cyclic peptides, which has great potential for novel therapeutic development. In summary, PepBAN serves as a valuable tool for advancing peptide-based drug and therapeutic development.
Shuaiyan Li, Xiaorui Wang, Yuchen Zhu et al.· Journal of Chemical Informat...· 2 citations
A new method, called CW-Net, translates the reasoning process of an autonomous vehicle’s AI system into understandable concepts that explain its behavior.
Known for his clear and elegant writing style, Bertsekas shaped fields from control and optimization to large-scale computation and artificial intelligence.
