Clinical guidelines underscore the importance of regularly monitoring and surveilling arteriovenous fistula (AVF) access in hemodialysis patients to promptly detect any dysfunction. Although phono-angiography/sound analysis overcomes the limitations of standardized AVF stenosis diagnosis tool, prior studies have depended on conventional feature extraction methods, restricting their applicability in diverse contexts. In contrast, representation learning captures fundamental underlying factors that can be readily transferred across different contexts. We propose an approach based on deep denoising autoencoders (DAEs) that perform dimensionality reduction and reconstruction tasks using the waveform obtained through one-level discrete wavelet transform, utilizing representation learning. Our results demonstrate that the latent representation generated by the DAE surpasses expectations with an accuracy of 0.93. The incorporation of noise-mixing and the utilization of a noise-to-clean scheme effectively enhance the discriminative capabilities of the latent representation. Moreover, when employed to identify patient-specific characteristics, the latent representation exhibited performance by surpassing an accuracy of 0.92. Appropriate light-weighted methods can restore the detection performance of the excessively reduced dimensionality version and enable operation on less computational devices. Our findings suggest that representation learning is a more feasible approach for extracting auscultation features in AVF, leading to improved generalization and applicability across multiple tasks. The manipulation of latent representations holds immense potential for future advancements. Further investigations in this area are promising and warrant continued exploration.
Li-Chin Chen, Yi-Heng Lin, Li-Ning Peng et al.· 0 citations
This paper presents an information-gain-guided reinforcement-learning sensor-selection framework for single-vessel tracking in heterogeneous maritime sensor networks. The proposed approach is motivated by information-theoretic sensor management: instead of activating all sensors or repeatedly performing computationally expensive online expected-information-gain evaluation, a learned policy selects one tracking-relevant sensor at each decision epoch. A Bayesian sequential Monte Carlo tracker estimates the vessel state from noisy measurements and provides a belief representation for scheduling under nonlinear and non-Gaussian conditions. A Proximal Policy Optimization agent selects one of five sensors in a georeferenced simulation of the CMMI Smart Marina testbed at Ayia Napa Marina, Cyprus. The policy is trained on the testbed's actual five-sensor configuration. The agent observes belief-state, detection-history, coverage, sensor-geometry, and realized-information-gain features. The reward is defined as a realized-information-gain term gated by an observability mask. Final-test simulations compare the proposed framework with random single-sensor selection, always-on sensing using all sensors simultaneously, and the expected-information-gain sensor-selection baseline proposed in our previous work. Results show that the learned policy achieves tracking performance close to always-on sensing while activating only one sensor per decision time step and avoiding the computationally expensive online entropy search required by expected-information-gain selection. Additional zero-shot evaluation without retraining on ten moderately perturbed versions of actual layout configuration showed broadly stable tracking, with any increase in positional tracking error remaining below 1 meter across all perturbations.
Andrei Starodubov, Yaqub Aris Prabowo, Andreas Hadjipieris et al.· 0 citations
Predictive modeling for clinical decision support requires both strong predictive performance and transparent, auditable, and human-reviewable decision logic. Although deep learning and tree-based ensemble methods can achieve high accuracy, their black-box nature remains a major obstacle to trustworthy clinical deployment. Moreover, clinical prediction often operates under practical constraints, including limited sample sizes, severe class imbalance, and feature evolution arising from changes in diagnostic criteria or clinical documentation practices. We propose Medical Heuristic Learning (MHL), a constrained paradigm for LLM-assisted rule learning. Rather than relying on updates to implicit model weights, MHL integrates statistical probes, medical knowledge probes, initial rule synthesis, and iterative rule optimization to construct an executable rule-based expert system. The resulting rule system is expressed entirely using the native logical and control-flow constructs of a programming language. Valid rule versions are recorded and retained along the search trajectory, making the decision logic explicit, interpretable, and auditable. MHL also supports continual learning by using previously validated rules as a starting point and iteratively revising them in response to updated feature information under data drift or feature evolution. MHL is not tied to any specific programming language. Comprehensive experiments on medical datasets show that MHL achieves predictive performance comparable to that of state-of-the-art methods, performs favorably in small-sample and highly imbalanced settings, and supports the transfer and adaptive revision of validated rules under feature evolution. Overall, these findings suggest that non-gradient-based heuristic systems offer an approach to balancing predictive performance and transparency in clinical decision support.
Leveraging Large Language Models (LLMs) to automatically formulate and solve optimization problems from natural language has emerged as an efficient paradigm for automated optimization. However, existing methods still exhibit limited generalization: they are sensitive to superficial narrative variations, reuse experience mainly at the case level, and struggle to adapt to shifted or emerging problem types. We propose OptSkills, an archetype-centric skill learning and reasoning agent system for optimization modeling and solving. To improve robust generalization, our system clusters problems by their underlying archetypes rather than surface narratives. To improve in-distribution generalization, it explores diverse modeling paradigms and solver configurations within each cluster, then distills successful trajectories into reusable workflow-level skills. To improve out-of-distribution generalization, it refines existing skills or expands the skill library using newly obtained trajectories. Our system achieves a state-of-the-art micro-averaged accuracy of 68.27% on datasets encompassing diverse problem types and scenarios. In addition, on MIPLIB-NL, a highly challenging large-scale and high-dimensional benchmark, it achieves 26.91% accuracy, outperforming DeepSeek-V3.2-Thinking by 4.53%. After skill learning on Nano-CO, it reaches 72.79% on the OOD NLCO benchmark. Code and skills are available at https://github.com/fujiwaranoM0kou/OptSkills.
Haochen Yang, Ke Zhao, Mengyuan Ma et al.· 0 citations
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While Artificial Intelligence (AI) offers transformative potential for operational performance, its deployment in safety-critical domains such as aviation requires strict adherence to rigorous certification standards. Current EASA guidelines mandate demonstrating complete coverage of the AI/ML constituent's Operational Design Domain (ODD) -- a requirement that demands proof that no critical gaps exist within defined operational boundaries. However, as systems operate within high-dimensional parameter spaces, existing methods struggle to provide the scalability and formal grounding necessary to satisfy the completeness criterion. Currently, no standardized engineering method exists to bridge the gap between abstract ODD definitions and verifiable evidence. This paper addresses this void by proposing a method that integrates parameter discretization, constraint-based filtering, and criticality-based dimension reduction into a structured, multi-step ODD coverage verification process. Grounded in gathered simulation data from prior research on AI-based mid-air collision avoidance research, this work demonstrates a systematic engineering approach to defining and achieving coverage metrics that satisfy EASA's demand for completeness. Ultimately, this method enables the validation of ODD coverage in higher dimensions, advancing a Safety-by-Design approach while complying with EASA's standards.
Thomas Stefani, Johann Maximilian Christensen, Elena Hoemann et al.· 0 citations
A long-standing challenge in AI is to develop agents capable of solving a wide range of physical tasks and generalizing to new, unseen tasks and environments. A popular recent approach involves training a world model from state-action trajectories and subsequently use it with a planning algorithm to solve new tasks. Planning is commonly performed in the input space, but a recent family of methods has introduced planning algorithms that optimize in the learned representation space of the world model, with the promise that abstracting irrelevant details yields more efficient planning. In this work, we characterize models from this family as JEPA-WMs and investigate the technical choices that make algorithms from this class work. We propose a comprehensive study of several key components with the objective of finding the optimal approach within the family. We conducted experiments using both simulated environments and real-world robotic data, and studied how the model architecture, the training objective, and the planning algorithm affect planning success. We combine our findings to propose a model that outperforms two established baselines, DINO-WM and V-JEPA-2-AC, in both navigation and manipulation tasks. Code, data and checkpoints are available at https://github.com/facebookresearch/jepa-wms.
Basile Terver, Tsung-Yen Yang, Jean Ponce et al.· 0 citations
Competitive programming has become a key test of large language model reasoning, with international competitions such as IOI and ICPC representing its most challenging settings. We present an end-to-end specialization pipeline combining large-scale problem curation, synthetic reasoning traces, supervised fine-tuning (SFT), and reinforcement learning (RL). Using 22,000 curated problems, we train Nemotron-3-Nano-CC (30B-A3B) with SFT and RL and Nemotron-3-Ultra-CC (550B-A55B) with SFT alone. We further introduce GenCorrect, a feedback-driven test-time compute strategy that iteratively generates, evaluates, and refines diverse solutions. On IOI 2025, Nano-CC improves from 130 points to 291 after post-training and to 468 with GenCorrect, exceeding the gold threshold of 438.3 while Ultra-CC reaches 502. Guided by these results, we develop a competition-specific Ultra-CC system and evaluate it prospectively during IOI 2026. Under the same time, internet-access, and submission constraints as human contestants, it scores 535.4 out of 600, exceeding both the gold threshold of 361.12 and the top human score of 498.27. To our knowledge, this is the first AI system to outscore the highest-scoring human contestant on an IOI problem set.
Aleksander Ficek, Sean Narenthiran, Mehrzad Samadi et al.· 0 citations
People increasingly use language models to support life decisions. Many such decisions involve a probabilistic forecast: How likely is a major life event, a natural disaster, or an economic outcome? Users of language models may implicitly trust that these forecasts fall out of a coherent world model. In this paper, we evaluate the coherence of language model probabilistic forecasts through a procedure that builds on a theorem due to de Finetti. We elicit forecasts from language models across events generated from stock returns data. We then use linear programs to compute the largest Dutch-book profit - the profit an arbitrageur could guarantee by betting against model-generated probabilities - which we use as a measure of incoherence. Our procedure does not require outcome labels, so we can evaluate coherence even in settings where outcomes are not observed or have not yet resolved. We find substantial evidence of incoherence in language model forecasts. Such incoherence increases when there are richer logical relationships between events, and irrelevant contextual details can increase incoherence by an order of magnitude. We conclude by discussing how alternative training strategies may improve probabilistic coherence.
Training data attribution (TDA) aims to identify training examples that shape model behavior, but its intervention value depends on both which examples are selected and how they are modified. Influence functions (IF) estimate behavioral changes under infinitesimal reweighting, yet IF-selected examples often show limited advantages over random selection under conventional weight-based interventions. This raises the question of whether influential examples lack intervention value or whether reweighting fails to realize their behavioral leverage.We introduce influence-guided response rewriting, which uses IF to identify intervention targets and replaces their responses with behavior-aligned or behavior-opposed supervision while keeping instructions fixed. Across four open-weight LLMs, we compare rewriting and reweighting on the same influence-selected examples using epistemic abstention as our primary testbed. Response rewriting produces stronger, more persistent, and bidirectional behavioral shifts, while reweighting the same examples yields weak and inconsistent effects. Further analyses show that influence-selected examples provide greater rewriting leverage than alternative selectors, with changes remaining concentrated on target-relevant behaviors. The same qualitative contrast extends to safety refusal. These results distinguish the local reweighting effects captured by influence estimates from the broader intervention leverage of the examples they identify, motivating intervention-aware evaluation of TDA methods.
Yuzhang Luo, Chenpeng Wang, Jianhui Chen et al.· 0 citations
Large language models now answer medical questions with expert-level performance. However, the context these systems act on can be misleading, and misleading context can corrupt a model's medical judgment. To understand how misleading context corrupts this judgment, we examine the model's susceptibility to the context, disclosure of it, mechanism of corrupted reasoning, and monitorability of the decision. On the medical reasoning subset of MedMisBench, a clinician-reviewed question-answering benchmark of 8,627 questions, we inject two types of misleading context cues, fabricated evidence and a bare assertion. We test three reasoning models, two that expose their full reasoning trace and one frontier model that exposes only its response. All three are more susceptible to the assertion than to the fabricated evidence, adopting the asserted answer 10 to 27 points more often. The misleading cues are disclosed in 81 to 98% of traces but only 7 to 90% of responses, and the assertion is disclosed less often than evidence based cues. Resampling from reasoning traces without disclosure shows the two cues corrupt reasoning differently, evidence entering early and accumulating while the assertion redirects the conclusion near its end. An LLM monitor catches 78% of corrupted decisions at 5% false positives when reading an open model's trace with guidance, against at most 32% from any response. The misleading context that models are most susceptible to is disclosed least, and was caught reliably only from an open reasoning trace, which frontier providers withhold.
Polymeric materials are central to modern technologies, with applications ranging from energy to health and transportation. Although AI has made significant advances in materials discovery, the hierarchical structure of polymers across multiple length scales makes them inherently difficult to represent in a unified and physically meaningful way. Here we introduce HiPoly, a polymer-native AI framework that processes complete polymer descriptions through a three-level hierarchical graph architecture built on the G2RINS representation. HiPoly encodes stochastic inter-monomer connectivity, composition, and molecular weight directly within its architecture, using physically motivated design principles that mirror the multi-scale nature of polymeric systems. The framework establishes an end-to-end AI-driven workflow from experimental formulation data to property prediction, generative molecular design, and physics-based validation through molecular simulations, all unified by a single polymer representation. We demonstrate state-of-the-art prediction accuracy for thermophysical properties of multi-component polymer systems, with ablation studies confirming that each hierarchical design choice contributes independently to model performance. As an example, the generative design pathway is applied here to the discovery of sustainable alternatives to persistent fluorinated polymers, where it is possible to identify and independently validate PFAS-free candidates with target surface-energy properties. This work demonstrates how polymer-native AI can accelerate discovery by linking representation, prediction, and design across complex polymer chemistries.
Ge Sun, Gervasio Zaldivar, Yuan Tian et al.· 0 citations
Language models spend most of their attention on a small fraction of context, yet they read the entire KV cache to find the few tokens that matter. If the user asks about a previous detail in a 1M-token conversation, global attention layers must scan the full context to generate each token of the reply. A prominent approach mitigates this cost by pre-selecting relevant tokens via lightweight proxy scores, but this extrinsic scoring still incurs O(N) per step. We take an intrinsic approach motivated by the simple question: wouldn't the model already know which parts of the context are relevant? To this end, we introduce Declarative Attention (DA), a protocol that elicits the model to declare where it needs to attend within its chain-of-thought, partitioning generation into three modes:(full context),(a specific region), and(recent output only). The inference engine parses these declarations like tool calls and skips most of the KV cache read. Under zero-shot evaluation across 15 long-context tasks, DA on off-the-shelf models (Gemma-4-31B, Qwen-3.6-27B) significantly reduces total attended tokens during decoding (52.0%, 31.1%) with modest accuracy drops (1.27pp, 2.75pp) that shrink with model scale. DA unlocks a new axis of sparse attention, with further potential under training-based methods that future work can explore.
Namgyu Ho, Huzama Ahmad, Woosung Koh et al.· 0 citations
A new machine-learning framework aims to improve the success rate of computational protein design while moving away from results that reproduce sequences found in nature.
MIT News · Artificial Intelligence· news.mit.eduAug 24, 2026
A new method for surgically removing training examples from a model reveals that as datasets grow, the link between what a model learns and what it produces dissolves.
