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Single-cell transcriptomics and functional analyses identified SPIN.DOC as a regulator for Wnt signaling and cancer stemness in colorectal cancer

Khuraijam Mrinalini Devi Eshan Abbas Thangjam Davis Singh Rubismita Deka Aditya Kumar L. S. Singh Thiyam Ramsing Singh
Aug 2026 · Human Cell · Vol 39 · 0 citations · 47 references
Medicine

TL;DR

Investigating SPIN.DOC expression in a cohort of normal, primary human colorectal cancer (CRC) and metastatic tissues from CRC patients revealed differential expressions of SPIN.DOC across multiple cell clusters in different conditions and with the highest expression observed in tumor samples, suggesting its potential role in CRC progression.

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