Sep 2026· Naunyn-Schmiedeberg's Archives of Pharmacology· 0 citations· 37 references
Medicine
TL;DR
The utility of integrating multiomics, pharmacogenomic, structural, and single-cell approaches for therapeutic target discovery and prioritization in cancer is demonstrated.
Platinum resistance remains a central barrier to durable disease control in ovarian cancer. In this study, we integrated an ovarian cancer susceptibility GWAS, multi-omics profiling (CPTAC/TCGA), and spatial-single-cell transcriptomics to identify novel therapeutic targets. Cross-platform prioritization nominated m...
Feng Jin, Fang-Xin Li, Xiao-Ao Pang et al.· Cell Biology and Toxicology· 0 citations
Tetratricopeptide repeat domain protein 39B (TTC39B) is a lipid metabolism–related gene recently implicated in cholesterol regulation. However, its clinical and biological relevance in human cancers remains undefined.
Based on multi-omics data from the Cancer Genome Atlas (TCGA) pan-cancer dataset represen...
Hui-Juan Yi, Yan Wang, Chen-Hao Zhao et al.· BMC Medical Genomics· 0 citations
Triple-negative breast cancer (TNBC) is characterized by high malignancy, poor prognosis and a lack of specific therapeutic targets. Obesity acts as a major risk factor facilitating TNBC progression, while the molecular features underlying their correlation remain poorly systematically characterized. In this study, w...
Background: Prostate cancer (PCa) is a malignancy with high metastatic potential and poor prognosis, underscoring the urgent need for effective biomarkers and therapeutic targets to improve clinical management. Methods: An integrative multi-omics analysis combined with machine learning algorithms was performed to ident...
It is implied that in prostate cancer, the DNHD1-HDAC6 axis, a novel regulatory pathway, promotes aggressiveness and that HDAC6 is a targetable mediator of DNHD1-driven malignancy.
An-Nie-On-Nei Lee, Chia-Chang Wu, Su-Wei Hu et al.· Oncology Report· 0 citations
In the analyzed TNBC datasets, P2RX4 expression was associated with CD163 expression and hypoxia-related transcriptional features, and across transcriptomic analyses, P2RX4 expression was positively associated with CD163 expression and hypoxia-related transcriptional features.
Yi-Fei Meng, Yong-Qiu Zhu, Yue Zhang et al.· BMC Medical Imaging· 0 citations
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