This review provides a comprehensive overview of cytokine-mediated neuroinflammation in Alzheimer's disease, focusing on the cellular sources of cytokine production within the brain, including microglia, astrocytes, neurons, and endothelial cells.
This review examines the molecular and cellular mechanisms through which neuroinflammation contributes to the progression of AD, with particular emphasis on microglial activation, TREM2 and soluble TREM2 (sTREM2) signaling, NLRP3 inflammasome activation, astrocyte–microglia interactions, and blood–brain barrier dysfunc...
Shreyansh Goswami· International Journal For Mu...· 0 citations
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...
Almas Meheboob Pathan· International Journal of The...· 0 citations
Findings support a move from general anti-inflammatory treatment toward stage-based, biomarker-guided immune regulation, which may reduce cytokine damage while maintaining microglial clearance and repair, and support developing immune-regulating treatments for AD.
Ya-Wen Deng· Theoretical and Natural Scie...· 0 citations
Key results show that using anti-inflammatory drugs and therapies that support calcium balance can effectively interrupt the pathological cycle between neuroinflammation and excitotoxicity, and Simultaneously targeting multiple interconnected pathogenic pathways is a promising therapeutic strategy for reducing neurodeg...
Mayank Saini, Tanuj Hooda, Anushka Sood et al.· Current Chemical Biology· 0 citations
Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.
Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al.· Molecular and cellular neuro...· 0 citations
The molecular mechanisms underlying NLRP3 inflammasome activation in Alzheimer’s disease, its interaction with pro-inflammatory cytokine networks, and the emerging role of inflammasome-related biomarkers in disease characterization are examined.
Hira Shabbir· Scholars International Journ...· 0 citations
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