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Open access Aug 2026

Caspase-8 Polymorphism and Colorectal Cancer Risk: A Meta-Analysis of 35,854 Subjects

Objective Caspase-8 (CASP8) is essential for apoptotic clearance of transformed cells and is encoded by the CASP8 gene. The CASP8 -652 6N del polymorphism (rs3834129) has been studied in relation to colorectal cancer (CRC) risk with conflicting outcomes. This meta-analysis aims to provide a consolidated assessment of t...

Jun Wang, C. Ye · 0 citations
Open access 2026

The association of TLR2 and TPA genetic polymorphisms with colorectal cancer risk

Background/Aim: Colorectal cancer is the second most common cancer in women and the third most common in men. It is the third leading cause of cancer death worldwide. Statistics suggest a worrying increase in the incidence of this cancer in the coming years. Many factors, including family history, age, smoking habits a...

Mohammad Javan-Fekr, Mohammad-Hossein Sabzevari, I. Saadat · 0 citations
Open access Jan 2026

Association of CYP3A5 Genetic Variants With Elevated Breast Cancer Risk: A Case–Control and In Silico Analysis

Background Cytochrome P450 3A5 (CYP3A5) is a key xenobiotic‐metabolizing enzyme that also participates in the biotransformation of endogenous substrates. Functional genetic variation within CYP3A5 can alter enzyme activity and may consequently modify individual susceptibility to malignancy. The contribution of CYP3A5 g...

Sm Faysal Bellah · 0 citations
Open access Sep 2026

Impact of EXO1 (K589E) Genetic Variant on Breast Cancer Risk: Evidence From Bangladesh

Exonuclease 1 ( EXO1 ) is a key nuclease in the DNA mismatch repair (MMR) pathway and is involved in correcting replication errors while maintaining genomic stability. The K589E (rs1047840) single nucleotide polymorphism (SNP) of EXO1 has been associated with cancer susceptibility in different populations....

Mahmudul Kabir, M. Rahman, Sm Faysal Bellah et al. · 0 citations

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