Aug 2026· Journal of Neuropathology and Experimental Neurology· 0 citations
Medicine
TL;DR
It is proposed that early AEO-HS is associated with mitochondrial dysfunction, whereas non-mitochondrial factors are associated with late AEO-HS, suggesting neuroprotective mechanisms in late AEO.
OBJECTIVE
Despite representing the most common and fastest growing form of epilepsy in older adults, the clinical features of late onset epilepsy (LOE) and how it differs from early onset epilepsy (EOE) remain largely underexplored. Therefore, we evaluate the characteristics and risk factors of LOE compared to EOE.
M...
Syeda Amrah Hashmi, Mark Quigg, M. Abbas et al.· Epilepsia· 0 citations
Objective. Temporal lobe epilepsy (TLE) is associated with disrupted functional integrity in the amygdala-hippocampus complex. Cortico-cortical evoked potentials (CCEPs) can characterize this disruption and have been proposed as biomarkers of the epileptogenic zone (EZ), but their study is typically limited by the spat...
O. Feys, M. Josyula, Nilu Sinha et al.· medRxiv· 0 citations
Temporal lobe epilepsy (TLE) is increasingly conceptualized not as an isolated hippocampal lesion, but as a complex, multiscale limbic network connectomic disorder. Despite advances in pharmacological management, over 30% of patients experience drug-resistant epilepsy, underscoring the urgent need to shift from symptom...
Károly Orbán-Kis, K. Kelemen, Rita-Judit Kiss et al.· International Journal of Mol...· 0 citations
The results expand and refine the understanding of the thalamus as a region showing robust and recurrent associations across multiple clinical conditions of TLE and distinguish its role in pre- versus postsurgical brain organization with respect to seizure and neuropsychological outcomes.
Findings support the utility of plasma p-tau217 as a biomarker in this population and underscore the role of sleep processes in the relationship between neurodegenerative pathology and cognition in older adults with epilepsy.
R. Sarkis, Hyun-Sik Yang, Lei Liu et al.· Neurology· 0 citations
The cellular and molecular underpinnings of hippocampal sclerosis, cortical and subcortical atrophy, white matter and network level changes, and the emerging use of structural biomarkers are discussed, while highlighting therapeutic strategies that may attenuate or reverse these structural sequelae.
O. Kolawole, O. Fabiyi, O. Olayinka et al.· World Journal of Biology Pha...· 0 citations
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