Healthy lifestyle and related metabolomic signatures associated with decreased risk and delayed progression of type 2 diabetes mellitus transitions: a large prospective cohort study.

Oxidative balance-related metabolite signature and incident cardiovascular disease and type 2 diabetes within the PREDIMED trial.

Most metabolites showed biologically plausible patterns, correlating with specific pro- and antioxidant exposures and including metabolites previously implicated in oxidative stress-related processes, and inversely associated with CVD and T2D risk at baseline.

Metabolomic signatures of data-driven type 2 diabetes subtypes and their associations with dementia and stroke risk

From disease-free status to cardiometabolic multimorbidity: Metabolomic signatures associated with cardiometabolic progression.

BACKGROUND Although research has focused on metabolomic profiles linked to individual cardiometabolic diseases, there is a lack of studies on metabolomic signatures associated with cardiometabolic multimorbidity. METHODS We included 79,712 participants without cardiometabolic disease from the UK Biobank, randomly div...

Healthy lifestyle is associated with lower infection incidence in type 2 diabetes: A prospective cohort study with multi-omics mediation analysis

Maintaining an ideal lifestyle and higher LE8 scores was associated with lower infection incidence rate in T2DM, partly mediated by lipid metabolism and immune-inflammatory pathways.

Associations of cardiometabolic burden with cardiovascular disease–death transitions in metabolic dysfunction-associated steatotic liver disease: a prospective cohort study using multistate analysis

Aim To examine the associations of cardiometabolic burden with transitions from CVD-free status to incident CVD, death without prior CVD, and death after CVD among individuals with MASLD, and to further characterize non-linear patterns, temporal variations, and potential contributing factors related to these associatio...

Metabolomic profiling refines cardiovascular risk stratification beyond SCORE2-diabetes in patients with concurrent type 2 diabetes and pulmonary dysfunction

In participants with T2D and LFI, adding a metabolomic signature to SCORE2-Diabetes produced a statistically significant but moderate improvement in risk discrimination, which supports further evaluation in independent cohorts and prospective impact studies.