Aug 2026· British Journal of Nutrition· pp.
1-33
· 0 citations
Medicine
Abstract
Prospective evidence linking overall diet quality to gastroesophageal reflux disease (GERD) is limited, and metabolic pathways remain unclear. In a cohort of 183,878 adults free of GERD at baseline, we examined nine dietary pattern scores derived from repeated 24-hour dietary recalls and assessed associations with incident GERD over a median follow-up of 13.2 years, during which 15,401 cases occurred. Higher adherence to healthy patterns including MED, MIND, DASH, and DI-GM was associated with lower GERD risk (highest vs lowest tertile HRs 0.87-0.89), whereas a pro-inflammatory pattern (E-DII) was linked to higher risk (HR 1.11). In a metabolomics sub-cohort (N=98,669), diet-related NMR metabolomic signatures, derived from 168 biomarkers using Elastic Net regression, reflected similar associations and mediated 11.1%-32.2% of the diet-GERD relationship. Associations were largely consistent across subgroups and robust in sensitivity analyses, supporting a potential role of systemic metabolic profiles in mediating the effects of diet on GERD and highlighting metabolic mechanisms underlying diet-related disease risk.
ABSTRACT Using a cohort of 893 adults who underwent medical check-ups with rich data collection across diet, lifestyle, clinical labs, cardiac stress testing, and microbiome profiling, we show that a gut microbial health index (MHI), originally defined using a large meta-analysis of various human disease cohorts, is al...
T. Braun, Orli Harounian, R. Hadar et al.· Gut microbes· 0 citations
Background: Higher adherence to the EAT-Lancet diet is associated with lower risk of cardiovascular disease (CVD) and all-cause mortality. Metabolomic profiling can identify biomarkers underlying these associations. Objective: To investigate metabolomic markers of the EAT-Lancet diet and risk of CVD and all-cause morta...
Wan-Jin Guan, Jia-Qi Yang, Jing-Sha Chen et al.· Journal of NutriLife· 0 citations
Introduction Evidence linking flavonoid-rich dietary patterns to the risk of Parkinson's disease (PD) remains limited and inconsistent, and molecular clues to this association remain scarce. This study examined the association between a flavonoid diet score (FDS) and incident hospital-recorded PD and explored related p...
Wen Yang, Zhe-Tian Chen, Yuan-Yuan Zhang et al.· Frontiers in Nutrition· 0 citations
A nuclear magnetic resonance-derived metabolic signature partially mediates the protective effect of healthy sleep on stroke risk through lipid metabolism, amino acid homeostasis, and systemic inflammation pathways, highlighting potential metabolic targets for stroke prevention in individuals with sleep disturbances.
Zhe Xu, Jinxiang Zhang, Zhi-Xing Fan et al.· Sleep Health· 0 citations
Higher diet quality is associated with favourable levels of blood-based biomarkers in older adults, with distinct associations within the metabolic and inflammatory domains, supporting the role of diet in promoting healthier aging.
Rachel Ann DaCosta, Caterina Gregorio, A. Calderón-Larrañaga et al.· BMC Medicine· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.
