[Berberine attenuates necrotizing enterocolitis-associated brain injury via the TLR4/MyD88/NF-κB/NLRP3 pathway].

Histopathology and NF-κB/Caspase-3 Expression in High Fructose Corn Syrup–Induced Lung Injury: Protective Effect of Dexpanthenol

DEXP exerts strong histoprotective and immunomodulatory actions, suggesting potential therapeutic value against HFCS-induced pulmonary injury, and chronic ingestion of HFCS elicits prominent inflammatory, apoptotic, and fibrotic responses in rat lung tissue.

Astragaloside IV mitigates mitochondrial damage and neurological symptoms in rats with cervical spondylotic myelopathy by inhibiting IL-17/TRAF6/NF-κB pathway.

Monotropein alleviates neuroinflammation in a rat model of cerebral ischemia/reperfusion injury by regulating NLRP3-mediated pyroptosis: an integrated in vivo and in silico analysis

Melatonin ameliorates NEC-associated brain injury by suppressing pro-inflammatory (M1-like) microglia via the AMPK-IL-1β axis.

BACKGROUND Necrotizing enterocolitis (NEC) is a severe neonatal gastrointestinal disease. Its associated brain injury involves neuroinflammation and long-term cognitive impairment, yet specific therapies are lacking. Melatonin (MEL) has shown neuroprotective effects, but its role in NEC-associated brain injury remains...

Targeting TRAF6/MYD88/TLR4, Nrf2, and VEGF signaling pathways by Tranexamic acid as a Novel Therapeutic Approach Protects Against Isotretinoin-Induced Liver Toxicity in Rats.

TXA effectively protects against isotretinoin-induced hepatotoxicity, primarily through antioxidant and anti-inflammatory mechanisms, primarily through antioxidant and anti-inflammatory mechanisms.

Research on the Mechanism by Which Lysophosphatidylcholine Regulates the Inflammatory Response in Ischemic Stroke Through the NF-κB Signaling Pathway

Background: Neuroinflammation following ischemic stroke is a significant factor leading to secondary brain damage, but the role of lysophosphatidylcholine (LPC) in this process remains unclear. This study sought to determine whether LPC participates in the post-ischemic inflammatory process and to evaluate if this effe...