Jul 2026· Journal of Clinical Ultrasound· 0 citations· 79 references
Medicine
TL;DR
The role of CCTA is summarized in risk stratification, therapeutic monitoring, and personalized coronary artery disease management, which links plaque vulnerability with functional ischemia.
Abstract
High-risk coronary plaque underlies major adverse cardiovascular events, shifting coronary imaging beyond luminal stenosis toward plaque characterization. CCTA identifies vulnerable features including low-attenuation plaque, positive remodeling, spotty calcifications, and napkin-ring sign, while enabling quantification of plaque burden and composition. Dual-energy and photon-counting CT improve tissue characterization, whereas AI and radiomics support automated analysis. Integration with FFR-CT and CT or MR perfusion imaging links plaque vulnerability with functional ischemia. Beyond diagnosis, CCTA enables longitudinal monitoring of plaque remodeling and stabilization under therapy. This review summarizes the role of CCTA in risk stratification, therapeutic monitoring, and personalized coronary artery disease management.
Pericoronary adipose tissue (PCAT) imaging has emerged as a promising noninvasive marker of coronary inflammation and an adjunctive risk-stratification tool beyond conventional coronary computed tomography angiography (CCTA) findings such as luminal stenosis and plaque morphology. The fat attenuation index (FAI), deriv...
M. Hoshino, T. Yonetsu, T. Kakuta et al.· Journal of Cardiology· 0 citations
Atherosclerotic cardiovascular disease (ASCVD) is the leading global cause of death and evolves over decades through a prolonged subclinical phase, providing a critical opportunity for early detection and prevention. Traditional risk prediction models estimate future cardiovascular risk but may under- or overestimate i...
V. Sorin, Kemi Fatade, Michael F. Morris et al.· Radiographics· 0 citations
Coronary CT angiography (CCTA), long confined to a diagnostic triage role, now occupies a central place at every stage of coronary artery disease management. Diagnostically, it overcomes the limitations of the calcium score - blind to non-calcified plaque - by directly visualizing the arterial wall, and now integrates...
Antoine Delapierre, G. Tonnerre, F. Mokrane et al.· Annales de cardiologie et d'...· 0 citations
PURPOSE OF REVIEW
Nonobstructive coronary artery disease (NOCA) is now frequently detected by coronary CT angiography (CCTA), but the term compresses biologically distinct patterns into a single anatomic label. This review examines how CT-derived markers can reorganize NOCA around plaque burden, inflammatory activity,...
P. Piña, A. Filtz, Daniel Lorenzatti et al.· Current Opinion in Cardiolog...· 0 citations
RATIONALE
The time-dependent contributions of coronary atherosclerotic plaque burden and myocardial ischemia to clinical outcomes in suspected coronary artery disease (CAD) remain uncertain. This study aimed to evaluate the temporal associations of quantitatively assessed plaque burden and ischemia with cardiovascular...
J. Dahdal, T. Maaniitty, R. Jukema et al.· European Journal of Nuclear...· 0 citations
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