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Bap1-mediated deubiquitination determines immune tolerance and anti-tumor immunity via modulating eTreg cell differentiation and ferroptosis.

Hai-Yan Liu Yan-Hong Su Danni Chen Boxiao He Ning Yuan Qianhao Wang Bao-Jun Zhang Zhaozu Feng Xiao-Ran Zhang Yifan Yao Lei Lei Anjun Jiao Yi-Lei Zhang Bao-Jun Zhang

Aug 2026 · Cell Death and Differentiation · 0 citations · 93 references

Medicine

TL;DR

This work identifies the histone deubiquitinating enzyme Bap1 as a pivotal regulator of eTreg cell fate via its H2A deubiquitination activity to maintain immune tolerance and restrains antitumor immunity.

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